Am I the only one who sees a huge disconnect between protein designs and how efficiently they can be executed in the wet-lab? What do you think it’s missing?What could be done for it be improved? Are the datasets used to train those models not good enough anymore?What do you think? Best, Omar. © ProteinReach|2026 SciLearningWorkshops LLC Unsubscribe · Preferences

I came across a nanodisc-based purification approach that just changed how I think about membrane protein biochemistry. I wish I had known about this during my PhD.This approach, developed by Cube Biotech, allows the purification of membrane binding proteins without detergents. It relies instead on a copolymer based nanodisc technology.What makes this especially compelling is that the nanodiscs create an environment that closely resembles a native cell membrane.Here is what stood out to...

I just found a platform that lets you run Calvados force field simulations without touching a terminal.It's called FastFold, and it has a built in app for Calvados molecular dynamics simulations.Here's how simple it is:Go to FastFold, click on Apps, and open Calvados.You can input your own sequence of interest, or start with the examples section. There are several proteins to choose from, and I would recommend starting with lysozyme.Click on it and you'll be prompted to a settings page for...