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ProteinReach by Dr. Omar

Nanodisc-based protein purification

Published about 2 months ago • 1 min read

I came across a nanodisc-based purification approach that just changed how I think about membrane protein biochemistry.
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I wish I had known about this during my PhD.
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This approach, developed by Cube Biotech, allows the purification of membrane binding proteins without detergents.
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It relies instead on a copolymer based nanodisc technology.
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What makes this especially compelling is that the nanodiscs create an environment that closely resembles a native cell membrane.
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Here is what stood out to me:
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1)Compared to detergent based approaches, this nanodisc system produces proteins at higher purity and yield.
2)Protein homogeneity is significantly superior to what is typically achieved with detergent based methods.
3)Thermostability also appears to be better preserved in nanodisc purified proteins relative to detergent based purification.
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You can go from cell lysate to pure protein in just two hours.
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That kind of speed streamlines downstream applications such as cryo EM sample prep, enzyme activity assays, among others. Thus saving resources, time, and making the whole process more efficient.

Link to Cube Biotech: https://cube-biotech.com/

Best,

Omar.

© ProteinReach|2026 SciLearningWorkshops LLC

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